DISTURBANCES OF LIPID METABOLISM

Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats

Objective(s) This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. Materials and Methods Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total c...

Disturbances of Lipid Metabolism in Patients with Atherosclerosis; Clinical and Molecular Genetic Investigations

Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.

High glucocorticoid concentrations are accompanied by metabolic side effects such as high plasma triglyceride (TG) concentrations. Liver, brown adipose tissue (BAT) and white adipose tissue are important regulators of plasma TG. Exposure to 4°C reduces plasma TG concentrations, and we therefore aimed to study the interaction between glucocorticoid excess and 24 hours of exposure to 4°C on lipid...

Disturbances of glucose and lipid metabolism during treatment with new generation antipsychotics.

PURPOSE OF REVIEW The purpose of this paper is to review the recent literature about alterations of lipid and glucose metabolism in patients treated with second generation antipsychotics. This article also addresses possible underlying mechanisms of these changes and discusses ways of preventing these side-effects as well as their management. RECENT FINDINGS There is a considerable number of ...

PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

Male BALB/c mice fed with either a regular or high fat diet were exposed to 0, 5 or 20 mg/kg perfluorooctane sulfonate (PFOS) for 14 days. Increased body weight, serum glucose, cholesterol and lipoprotein levels were observed in mice given a high fat diet. However, all PFOS-treated mice got reduced levels of serum lipid and lipoprotein. Decreasing liver glycogen content was also observed, accom...